Freed et al (2001)

Freed et al (2001)

the role of dopamine in Parkinson's disease

Aim

To investigate the effects of dopamine on the behavioural symptoms of Parkinson’s disease.

Participants

40 patients with severe Parkinson’s disease (mean duration of the disease was 14 years, aging 34-75 years)

Method and design

Experiment; independent measures design

Neuroimaging technique

PET scan

Procedure 1/2

- In the experimental group cells with dopamine producing neurons were taken from aborted embryos and transplanted into the patient's brain (putamen) - In control group skull was drilled but there was no transplantation

Procedure 2/2

Patients were followed for one year. PET scans - estimate changes in the brain. Clinical observations and interviews - register changes in symptoms.

Results

PET scans revealed significant growth of dopamine producing cells in putamen of transplant group. Patients in the transplant group represented reduction of disease by 28% (only in the relatively younger group - below 60)