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anx124
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inhibitor kompetycyjny
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chinidyna
inhibitor niekompetycyjny
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ketokonazol
inhibitory oparte na mechanizmie dzialania wymagaja oksydacji przy udziale enzymu p450
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gestoden; dietylokarbamazyna
zwiekszaja aktywnosc oksydazy mikrosomalnej i ukladu sprzegajacego
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etanol; ryfampicyna; karbamazepina; karcynogenne zwiazki chemiczne
Najbardziej przebadane czynniki indukujace
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policykliczne aromatyczne hydrokarbony
leki aktywne farmakologicznie po zmetabolizowaniu
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azatiopryna -> merkaptopuryna; enalapryl -> enalapryt
metabolizm moze zmienic dzialanie leku jakiego?
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aspiryna -> kwas salicylowy
hepatotoksycznosc
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paracetamol
urotoksycznosc
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cyklofosfamid -> akroleina
podczas znieczulenia halotanem podaje sie
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disulfiram ktory hamuje enzym cyp2e1 i zmniejsza powstawanie kwasu trifluorooctowego
recyrkulacja ma znaczenie dla
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morfiny; etynyloestradiolu
lek wydalany w postaci niezmienionej
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wekuronium
lek wydalany po deacetylacji
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ryfampicyna
lek usuwany juz podczas pierwszego transportu do nerki
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penicylina
lek eliminowany powoli
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diazepam
lek zwiazany z albuminami w 98%
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warfaryna
lek w 80% zwiazany z bialkami osocza
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penicylina
leki o czasteczkach spolaryzowanych
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digoksyna i antybiotyki aminoglikozydowe
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