I wish the weather was nicer/It would stop raining. If only something exciting would happen. Why can't/won't these flies go away? I'd like to/I'd love to/I want to have a holiday right now. I'm dying to sit down. I'm dying for a drink (more emphatic).
I'd prefer to go out rather than sit here. I usually prefer walking to doing nothing/like walking better than doing nothing. I'd rather do something than just sit. I'd rather not stay here. I'd rather you came with me.
I'm going to give up my job. You're not, are you? Are you really? Really? Well, that is a surprise. Good heavens/Good Lord. You aren't going to sell the house, are you? aren't you going to work here any more?
Unfortunately/I'm afraid the car won't start. What a pity!/shame! It's a pity/shame it happened today. I'm sorry to say/I regret to say we're going to miss the show. I'm sorry not to have seen/I regret not having seen the show. (regret is more formal)