不管 in English:

no matter where you live

He got fired in spite of all his hard work.

She loved him in spite of the fact that he drank too much.

We went camping in spite of the weather

in spite of the rain

in spite of evidence, they did not belive him

He still smokes, in spite of all the health warnings.

He got fired in spite of all his hard work. I wasn’t cold in spite of the snow. I wasn’t cold despite the snow.

They travel abroad every year in spite of the cost.

Tina seems to be happy, in spite of her recent problems.

Jane's been unfaithful to Jim three times, but he still loves her in spite of everything.

in spite of this, lwe can continue

We can continue in spite of this,

He was suddenly cold in spite of the sun

in spite of