重大 in English:

He studied the scientists considered to be the most significant of the 19th century.

significant headway

It is a significant change in our policy. / In addition, they reported significant growth in their investment in 2005 and 2006. / The effect was significant from the first year.

My company is one of The most significant on The global market.

At present the text book issue between the Korean and Japanese governments is developing into a significant problem affecting both countries.

The significant point as regards the segregation problem is to clarify the value system of each group.

If this proposal is put into practice, the business world will be affected to a significant degree.

With text we mean any communicative situation of significant length.

What is significant in this argument is that his theory can identify those phenomena.

The workshops have a significant glass front, allowing maximum light and view of the interior from outside

The thin mist from yesterday will turn into thick fog at night which can cause adverse weather conditions for drivers as visibility will be significantly reduced.

Head office is very worried there was a significant decrease in the number of orders taken in the last quarter.

It is significant that Falkner did not attend the meeting himself. / → Opposite - insignificant

The scientists made a significant breakthrough. (Naukowcy dokonali istotnego przełomu.)

Great, isn't it?

A great warrior radiates strength. He doesn't have to fight to the death.

Though the Incas built up a great civilization, they had no system of writing.

If it were not for great books, our lives would be much the poorer.

Most people have great disinclinations to get out of bed early, even if they have to.

The cones of the jack pine, for example, do not readily open to release their seeds until they have been subjected to great heat.

Wouldn't it be great if a gender-neutral pronoun for "he" or "she" existed in English?

This drawing is less than great. He needs to do something with the line here at the back of the leg.

We humans have a great way of twisting facts to fit our conclusion as soon as we have made one.

All great men are dead and I am not feeling too well myself.

By the 1750s, all the tribes of the Great Plains had horses.

The small country is making great efforts to keep up with other developing countries.

A nation need not necessarily be powerful to be great.

Being written in great haste, this letter has quite a few mistakes.

General Lee and the Confederate Army lost the great battle.