Shame on you for getting so flustered. You looked ridiculous.
It's a shame that I had to quit my job just when I was getting the hang of things.
I think it's a shame that some foreign language teachers were able to graduate from college without ever having studied with a native speaker.
Youth is such a priceless commodity that it is a shame to waste it on children.
You've brought shame to this family, Cecil.
It would be a shame for a young man to be at loose ends just because he can't get the kind of job he wants.
Recently I've stopped being afraid of "living in shame" and being exposed to "public ridicule".
Shame be to him who thinks evil of it.
What with joy and shame, she blushed to the ears.
Japan's shame, the result of the Pacific War, has not yet faded.
I had rather never have been born than have seen this day of shame.
When Toby made fun of my new haircut I went red with shame.
Shame on you. / What a shame that you did not pass your exams.
In present day Japan, "alchemy" is only used metaphorically; to refer to improper means of making money by politicians or religious hucksters with no morals or shame.